Brother's Blood unfolds in the harsh and crumbling landscape of an urban setting, where a former inmate, newly freed, embarks on a vengeful killing spree targeting his old friends. He believes they betrayed him by allowing him to face the consequences alone for a crime they all committed together. As the death toll rises, one friend, who has since become a police officer, is determined to halt the deadly rampage and rectify the numerous injustices of their violently troubled history.